Flamingo (protein) - Search
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  1. Flamingo (protein) - Wikipedia

    • Flamingo is one of the core proteins in the planar cell polarity (PCP) pathway, which is required for successful body elongation during gastrulation in early development, as well as the formation of developing organs such as the brain, inner ear, and kidney. It has been extensively studied for its role in patterning developmental tissues in a wide range of species… See more

    Overview

    Flamingo is a member of the adhesion-GPCR family of proteins. Flamingo has sequence homology to cadherins and See more

    Protein structure

    Flamingo is an atypical cadherin, with a cadherin-like extracellular domain, composed of cadherin and EGF adhesive repeats, that can bind to other Flamingo proteins expressed on neighboring cells. The … See more

    SymbolCELSR2
    Alt. symbolsEGFL2
    NCBI gene1952
    OMIM604265
    Function in neurons

    In Drosophila, flamingo mutants were found to have abnormal dendrite branching, outgrowth and routing. Kimura et al. proposed that flamingo regulates dendrite branch elongation and prevents the dendritic tr… See more

     
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